Livedoid vasculitis
Livedoid vasculitis ndi matenda osatha akhungu omwe amawonekera makamaka mwa amayi achichepere mpaka azaka zapakati. Mawu amodzi omwe amagwiritsidwa ntchito pofotokoza mawonekedwe ake ndi “Zilonda zowawa za purpuric zokhala ndi mawonekedwe a reticular kumunsi kwa malekezero” (PURPLE). Iwo amagwirizana ndi matenda ambiri, kuphatikiza matenda a venous aakulu ndi varicosities.
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Ikhoza kukhala ndi ululu.
relevance score : -100.0%
ReferencesLivedoid vasculopathy ndi khungu losowa kwambiri lomwe limadziwika ndi zilonda zowawa zomwe zimabwereranso pa masiku a miyendo.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy ndi vuto la khungu lomwe limayambitsa zilonda zam'munsi zomwe zimatsala pang'ono ndipo zimasiya zipsera zotuwa zomwe zimadziwikanso kuti atrophie blanche. Ngakhale kuti chifukwa chenicheni sichikudziwikabe, akukhulupirira kuti kuchuluka kwa magazi kuundana (hypercoagulability) ndi chinthu chachikulu, pomwe kutupa kumakhala gawo lachiwiri. Zinthu zomwe zimachititsa kuti magazi aziundana ndi: kusowa kwa maproteni C ndi S, kusintha kwa ma gene monga factor V Leiden, kusowa kwa antithrombin III, kusintha kwa gene ya prothrombin, komanso kuchuluka kwa homocysteine. Mu biopsies, matendawa amawonetsa kutsekeka kwa magazi mkati mwa zotengera, kukhuthala kwa makoma a zotengera, ndi zipsera. Kuchiza kumaphatikizapo njira zingapo zomwe zimayang'ana kwambiri kuteteza magazi kuundana, monga mankhwala anti‑platelet, mankhwala ochotsa magazi, ndi fibrinolytic therapy. Mankhwala osiyanasiyana omwe amagwiritsidwa ntchito pa vuto ili ndi colchicine, hydroxychloroquine, vasodilators, ndi immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy ndi vuto lalikulu lomwe limabweretsa zotupa pa miyendo yonse. Mapangidwe a magazi m'mitsempha ya'mtu amaganiziridwa kuti amayamba chifukwa cha kuwonjezeka kwa magazi ndi kuchepa kwa magazi, komanso kuwonongeka kwa chotengeracho. Amakhala kwambiri pakati pa akazi, makamaka m'ma zaka 15 mpaka 50. Kusiya kusuta, kusamalira zilonda, ndi kugwiritsa ntchito mankhwala monga ochepetsa magazi ndi antiplatelet mankhwala kumathandiza.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
